Hybrid designs offer opportunities to study both implementation outcomes and effectiveness outcomes, and there are different types of hybrid designs based on the relative importance placed on those implementation and effectiveness outcomes. Dr. J.D. Smith’s presentation begins around the 6:30 minute mark. (Video; 47 minutes)

This seminar paper by Curran et al. (2012) introduced the effectiveness–implementation hybrid design framework, providing a practical typology that allows researchers to simultaneously evaluate clinical effectiveness and implementation processes, thereby accelerating the translation of evidence-based interventions into real-world practice.

In this more recent paper, Landes et al. (2019) clarify and operationalize effectiveness–implementation hybrid designs by providing a concise conceptual overview and practical guidance for selecting Hybrid Types 1–3, helping researchers more deliberately integrate effectiveness and implementation questions within a single study.