The establishment of the CCTS and the emergence of new research paradigms cutting across traditional basic, clinical, and translational science disciplines mandate significantly enhanced levels of data integration and the strategically developed bioinformatics architecture and associated processes to manage it. A number of advanced bioinformatics systems currently support UK’s comprehensive research and clinical care portfolio.However, much of this technology infrastructure is embedded in disparate units, and some has been developed as project-specific technology.Within these specialized resources, UK has particular strengths in biostatistics, bioinformatics, genomics, and statistics.The result is that isolated data-rich environments are in place at UK with sophisticated technological capabilities, but the means to share these resources in a cross-cutting fashion and to enable multiple levels of access across the spectrum of clinical care and the basic, clinical, and translational research enterprises constitute areas of serious need. In addition, UK’s statewide health care engagement at community–based hospital sites illuminates the broader need for an integrated biomedical informatics infrastructure to serve as the cornerstone for communication and data sharing with this extensive network of community collaborators. (See also the REACH function.)